Why won't it stop? The dynamics of benzodiazepine resistance in status epilepticus

RJ Burman, RE Rosch, JM Wilmshurst, A Sen… - Nature Reviews …, 2022 - nature.com
Status epilepticus is a life-threatening neurological emergency that affects both adults and
children. Approximately 36% of episodes of status epilepticus do not respond to the current …

The cognitive impact of antiepileptic drugs

CM Eddy, HE Rickards… - Therapeutic advances in …, 2011 - journals.sagepub.com
Effective treatment of epilepsy depends on medication compliance across a lifetime, and
studies indicate that drug tolerability is a significant limiting factor in medication …

Neurocognitive effects of antiseizure medications in children and adolescents with epilepsy

FMC Besag, MJ Vasey - Pediatric Drugs, 2021 - Springer
Impairments in cognition are common in epilepsy and may be caused or exacerbated by
antiseizure medications (ASMs). Positive effects on cognition may also be seen with some …

[PDF][PDF] Cognitive effects of antiepileptic drugs

SP Park, SH Kwon - Journal of clinical neurology (Seoul …, 2008 - synapse.koreamed.org
Patients with epilepsy often experience cognitive dysfunction. Multiple factors can adversely
affect cognition in epilepsy, including the etiology of the seizures, cerebral lesions acquired …

Antioxidants as a preventive treatment for epileptic process: a review of the current status

B Martinc, I Grabnar, T Vovk - Current neuropharmacology, 2014 - ingentaconnect.com
Epilepsy is known as one of the most frequent neurological diseases, characterized by an
enduring predisposition to generate epileptic seizures. Oxidative stress is believed to …

Current position of phenobarbital in epilepsy and its future

MJ Brodie, P Kwan - Epilepsia, 2012 - Wiley Online Library
This article reviews the current position of phenobarbital using articles published since 2000
and speculates on its likely future contribution to epilepsy care. Over the last decade there …

Neurocognitive effects of adjunctive levetiracetam in children with partial‐onset seizures: A randomized, double‐blind, placebo‐controlled, noninferiority trial

PM Levisohn, M Mintz, SJ Hunter, H Yang, J Jones… - …, 2009 - Wiley Online Library
Purpose: Evaluate potential neurocognitive effects of adjunctive levetiracetam in children
with inadequately controlled partial‐onset seizures (POS). Methods: Randomized, double …

Curcumin ameliorates cognitive dysfunction and oxidative damage in phenobarbitone and carbamazepine administered rats

KH Reeta, J Mehla, YK Gupta - European Journal of Pharmacology, 2010 - Elsevier
The antiepileptic drugs, phenobarbitone and carbamazepine are well known to cause
cognitive impairment on chronic use. The increase in free radical generation has been …

癫痫与认知功能关系的研究进展

陈美丽, 白宇 - 中国康复理论与实践, 2012 - cjrtponline.com
认知障碍是癫痫患者常见的伴随症状, 主要表现为注意力, 记忆力, 计划判断能力的下降.
随着社会医疗模式的转变, 在癫痫患者的治疗过程中, 其认知功能的损害是临床医生必经考虑的 …

Neuroinflammation impact in epileptogenesis and new treatment strategy

AM Mahfoz, N Shahzad - Behavioural pharmacology, 2019 - journals.lww.com
Epilepsy is considered a major serious chronic neurological disorder, characterized by
recurrent seizures. It is usually associated with a history of a lesion in the nervous system …