The Abelson (ABL) family of nonreceptor tyrosine kinases, ABL1 and ABL2, transduces
diverse extracellular signals to protein networks that control proliferation, survival, migration …

Chronic myeloid leukemia (CML) is probably the most extensively studied human
malignancy. The discovery of the Philadelphia (Ph) chromosome in 19601 as the first …

The bcr–abl oncogene, present in 95% of patients with chronic myelogenous leukemia
(CML), has been implicated as the cause of this disease. A compound, designed to inhibit …

We describe a novel cytoplasmic tyrosine kinase, termed BPK (B cell progenitor kinase),
which is expressed in all stages of the B lineage and in myeloid cells. BPK has classic SH1 …

Imatinib, a potent inhibitor of the oncogenic tyrosine kinase BCR–ABL, has shown
remarkable clinical activity in patients with chronic myelogenous leukaemia (CML) …

Summary bcl. 2-I-mice complete embryonic development, but display growth retardation and
early mortality postnatally. Hematopoiesis including lymphocyte differentiation is initially …

Abstract The amphetamine derivative (±)-3, 4-methylenedioxymethamphetamine (MDMA,
ecstasy) is a popular recreational drug among young people, particularly those involved in …

The development of B cells is dependent on the sequential DNA rearrangement of
immunoglobulin loci that encode subunits of the B cell receptor. The pathway navigates a …

Parkinson's disease is a movement disorder characterized by death of dopaminergic
substantia nigra (SN) neurons and brain accumulation of α-synuclein. The tyrosine kinase …

X-linked lissencephaly and" double cortex" are allelic human disorders mapping to Xq22. 3-
Xq23 associated with arrest of migrating cerebral cortical neurons. We identified a novel 10 …