CHIP/STUB1 ubiquitin ligase is a negative co-chaperone for HSP90/HSC70, and its
expression is reduced or lost in several cancers, including breast cancer. Using an …

The human ortholog of the Drosophila ecdysoneless gene (ECD) is required for embryonic
development and cell-cycle progression; however, its role in cancer progression and …

The p53 protein plays a central role in cell cycle arrest and apoptosis in response to diverse
stress stimuli. Human ecdysoneless (hEcd) is known for its role in stabilizing the p53 protein …

The steroid hormone ecdysone coordinates insect growth and development, directing the
major postembryonic transition of forms, metamorphosis. The steroid-deficient …

Identifying genetic cancer risk factors will lead to improved genetic counseling, cancer
prevention and cancer care. Analyzing families with a strong history of breast cancer (BC) …

Ecdysoneless (ECD) is an evolutionarily conserved protein whose germ line deletion is
embryonic lethal. Deletion of Ecd in cells causes cell cycle arrest, which is rescued by …

Pre-mRNA splicing catalyzed by the spliceosome represents a critical step in the regulation
of gene expression contributing to transcriptome and proteome diversity. The spliceosome …

Breast cancer is classified into different subtypes that are associated with different patient
survival outcomes, underscoring the importance of understanding the role of precursor cell …

High-risk human papillomaviruses (HPV), exemplified by HPV16/18, are causally linked to
human cancers of the anogenital tract, skin, and upper aerodigestive tract. Previously, we …

Co-transcriptional processing of nascent pre-mRNAs by the spliceosome is vital to
regulating gene expression and maintaining genome integrity. Here, we show that the …