In two landmark articles, Hanahan and Weinberg synthesized into one conceptual
framework 'the hallmarks of cancer', a massive amount of information describing the …

Combined with TCR stimuli, extracellular cytokine signals initiate the differentiation of naive
CD 4+ T cells into specialized effector T‐helper (Th) and regulatory T (Treg) cell subsets …

Mouse embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are in a
high-flux metabolic state, with a high dependence on threonine catabolism. However, little is …

CD49f (integrin subunit α6) regulates signaling pathways in a variety of cellular activities.
However, the role of CD49f in regulating the differentiation and pluripotency of stem cells …

It seems that the reception of Conrad Hal Waddington's work never really gathered speed in
mainstream biology. This paper, offering a transdisciplinary survey of approaches using his …

Pluripotent stem cells (PSC s) exist in multiple stable states, each with specific cellular
properties and molecular signatures. The mechanisms that maintain pluripotency, or that …

Prenatal alcohol exposure is one of the most significant causes of developmental disability
in the Western world. Maternal alcohol consumption during pregnancy leads to an increased …

The results of clinical trials using mesenchymal stem cells (MSCs) are controversial due to
the heterogeneity of human MSCs and differences in culture conditions. In this regard, it is …

Mesenchymal stem cells (MSCs) and pericyte progenitors (PPs) are both perivascular cells
with similar multipotential properties regardless of tissue of origin. We compared the …

Although the Oct4/Sox2 complex is crucial for maintaining the pluripotency of stem cells, the
molecular basis underlying its regulation during lineage-specific differentiation remains …