The permeability barrier imposed by cellular membranes limits the access of exogenous
compounds to the interior of cells. Researchers and patients alike would benefit from …

There are many peptides known that inhibit the entry of enveloped viruses into cells,
including one peptide that is successfully being used in the clinic as a drug. In this review …

Development of novel antimicrobial agents is a top priority in the fight against multidrug-
resistant (MDR) and persistent bacteria. We developed a panel of synthetic antimicrobial …

Tumour-derived exosomes (T-EXOs) impede immune checkpoint blockade therapies,
motivating pharmacological efforts to inhibit them. Inspired by how antiviral curvature …

The transfer free energies of the twenty natural amino acid side chains from water to
phospholipid bilayers make a major contribution to the assembly and function of membrane …

AR-23 is a melittin-related peptide with 23 residues. Like melittin, its high α-helical
amphipathic structure results in strong bactericidal activity and cytotoxicity. In this study, a …

Poration of bacterial membranes by antimicrobial peptides such as magainin 2 is a
significant activity performed by innate immune systems. Pore formation by soluble forms of …

Host recognition of microbial components is essential in mediating an effective immune
response. Cytosolic bacteria must secure entry into the host cytoplasm to facilitate …

Mutations in mitochondrial acylglycerol kinase (AGK) cause Sengers syndrome, which is
characterized by cataracts, hypertrophic cardiomyopathy, and skeletal myopathy. AGK …

Membrane-enveloped viruses are a leading cause of viral epidemics, and there is an
outstanding need to develop broad-spectrum antiviral strategies to treat and prevent …