Six GATA transcription factors have been identified in vertebrates, each of which contains a
highly conserved DNA binding domain consisting of two zinc fingers of the motif Cys-X2-Cys …

Previous work has demonstrated that lineage-specific transcription factors play essential
roles in red blood cell development. More recent studies have shown that these factors …

Chromatin loops juxtapose distal enhancers with active promoters, but their molecular
architecture and relationship with transcription remain unclear. In erythroid cells, the locus …

Blood cell development relies on the expansion and maintenance of haematopoietic stem
and progenitor cells in the embryo. By gene targeting in mouse embryonic stem cells, we …

Congenital heart defects (CHDs) are the most common developmental anomaly and are the
leading non-infectious cause of mortality in newborns. Only one causative gene, NKX2-5 …

The zinc finger transcription factor GATA4 has been implicated in heart development based
on its early expression in precardiogenic splanchnic mesoderm and its ability to activate the …

THE zinc-finger transcription factor GATA-1 (previously known as GF-1, NF-E1 or Eryf 1 (refs
1-5)) binds to GATA consensus elements in regulatory regions of theα-and β-globin gene …

Previous studies have suggested that the GATA4 transcription factor plays an important role
in regulating mammalian cardiac development. In the studies described in this report we …

The X chromosome-linked transcription factor GATA-1 is expressed specifically in erythroid,
mast, megakaryocyte, and eosinophil lineages, as well as in hematopoietic progenitors …

The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the
remarkable progress in chromatin research over the past three years. It has been …