The aryl hydrocarbon receptor (AhR) was first identified as the intracellular protein that
bound and mediated the toxic effects of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) …

Aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor. 2, 3, 7, 8-
tetrachlorodibenzo-p-dioxin (TCDD) is a classical exogenous synthetic ligand of AHR that …

Recently, we reported that tetrandrine, a natural alkaloid, could inhibit the
osteoclastogenesis and bone erosion through enhancing the ubiquitination and degradation …

The aryl hydrocarbon receptor (AhR) has been implicated in regulating skeletal progenitor
cells and the activity of bone-forming osteoblasts and bone-resorbing osteoclasts, thereby …

Dioxin exposures impact on bone quality and osteoblast differentiation, as well as retinoic
acid metabolism and signaling. In this study we analyzed associations between increased …

Kynurenine (Kyn) is a tryptophan metabolite that increases with age and promotes
musculoskeletal dysfunction. We previously found a sexually dimorphic pattern in how Kyn …

Gut dysbiosis with disrupted enterohepatic bile acid metabolism is commonly associated
with non-alcoholic fatty liver disease (NAFLD) and recapitulated in a NAFLD-phenotype …

Multipotent mesenchymal stem cells (MSCs) maintain the ability to differentiate into
adipogenic, chondrogenic, or osteogenic cell lineages. There is increasing concern that …

Bone metabolism is regulated by endocrine systems, so people exposed to polychlorinated
dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) may suffer adverse effects on bones and …

The rapid development of modern society has led to an increasing severity in the generation
of new pollutants and the significant emission of old pollutants, exerting considerable …