The skin is a complex organ that has devised numerous strategies, such as physical,
chemical, and microbiological barriers, to protect the host from external insults. In addition …

Psoriasis is a chronic inflammatory skin disease characterized by scaly indurated erythema.
This disease impairs patients' quality of life enormously. Pathological findings demonstrate …

The skin provides both a physical barrier and an immunologic barrier to external threats. The
protective machinery of the skin has evolved to provide situation-specific responses to …

Professional antigen-presenting cells (APCs) in the skin include dendritic cells, monocytes,
and macrophages. They are highly dynamic, with the capacity to enter skin from the …

Innate resistance to Candida albicans in mucosal tissues requires the production of
interleukin-17A (IL-17A) by tissue-resident cells early during infection, but the mechanism of …

Our assumptions on the identity and functions of Langerhans cells (LCs) of the epidermis
have undergone considerable changes. Once thought to be prototypic representatives of the …

Dendritic cells (DCs) are a heterogeneous population playing a pivotal role in immune
responses and tolerance. DCs promote immune tolerance by participating in the negative …

Psoriasis is a representative inflammatory skin disease occupied by large surface
involvement. As inflammatory cells and cytokines can systemically circulate in various …

Psoriasis is a common inflammatory skin disease involving interactions between
keratinocytes and immune cells that significantly affects the quality of life. It is characterized …

The use of preclinical animal models of psoriasis has significantly increased over the last
three decades, with each model having unique strengths and limitations. Some models …