HMG-CoA reductase inhibitors (statins) are a widely used class of drug, and like all
medications, have potential for adverse effects (AEs). Here we review the statin AE literature …

Transcriptional control of cellular energy metabolic pathways is achieved by the coordinated
action of numerous transcription factors and associated coregulators. Several members of …

Aims/hypothesis Many of the effects of resveratrol are consistent with the activation of AMP-
activated protein kinase (AMPK), silent information regulator T1 (SIRT1) and peroxisome …

The estrogen-related receptors (ERRs) comprise a small group of orphan nuclear receptor
transcription factors. The ERRα and ERRγ isoforms play a central role in the regulation of …

Skin, which is a protective layer of the body, is in constant contact with physical and
chemical environmental factors. Exposure of the skin to highly adverse conditions often …

Estrogen receptor related receptor (ERR) α was one of the first identified (1988) orphan
nuclear receptors. Many of the orphan receptors identified after ERRα were deorphanized in …

Mitochondria are a principal site for generation of reactive oxygen species (ROS) in the
heart. Peroxisome proliferator activated receptor γ coactivator 1α (PGC-1α) plays an …

Oxidative stress is a hallmark of metabolism-related diseases and a risk factor for
atherosclerosis. FoxO factors have been shown to play a key role in vascular endothelial …

Anorexia nervosa is a psychiatric disorder with an unknown etiology that is characterized by
an individual's preoccupation with their weight and body structure while denying the severity …

As transcriptional factors, nuclear receptors (NRs) function as major regulators of gene
expression. In particular, dysregulation of NR activity has been shown to significantly alter …