Disease progression is usually accompanied by changes in the biochemical composition of
cells and tissues and their biophysical properties. For instance, hallmarks of cancer include …

Beyond their many well-established biological aberrations, solid tumours create an
abnormal physical microenvironment that fuels cancer progression and confers treatment …

Despite recent advances in mammalian synthetic biology, there remains a lack of modular
synthetic receptors that can robustly respond to soluble ligands and in turn activate bespoke …

The mechanical regulation of Notch signaling is an emerging area of interest in cell biology.
Notch is essential in many physiological processes in which mechanical stress plays an …

The Notch pathway regulates a diverse array of cell fate decisions, making it an enticing
target in cancer therapy and regenerative medicine. During the early stages of Notch drug …

In mammalian cells, signalling pathways orchestrate cellular growth, differentiation and
survival, as well as many other processes that are essential for the proper functioning of …

A major goal in synthetic development is to build gene regulatory circuits that control
patterning. In natural development, an interplay between mechanical and chemical …

Introduction: Developmental engineering based on endochondral ossification has been
proposed as a potential strategy for repairing of critical bone defects. Bone development is …

The ability to visualize and track multiple biological processes in vivo in real time is highly
desirable. Bioluminescence imaging (BLI) has emerged as an attractive modality for non …

Background Ubiquitylation (ubi) of the intracellular domain of the Notch ligand Delta (Dl) by
the E3 ligases Neuralized (Neur) and Mindbomb1 (Mib1) on lysines (Ks) is thought to be …