Genetic manipulation of animal models is a fundamental research tool in biology and
medicine but is challenging in large animals. In rodents, models can be readily developed …

Myocardial infarction (MI) is the leading cause of mortality worldwide. Despite the use of
evidence-based treatments, including coronary revascularization and cardiovascular drugs …

During the preclinical research process, multiple factors can be difficult to implement without
the careful consideration and planning of each step. As research has become more …

Objective Delayed cardiac tamponade, a life‐threatening complication of pericardial effusion
in humans, has rarely been described in large animal models. We report here a pig with …

Background There is a need for a targeted, comprehensive, minimally invasive myocardial
restoration treatment aimed at patients with chronic postinfarction heart failure that can …

Introduction: Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) are
a great source of human cardiac cells and can be combined with biomaterials to form …