There has been considerable speculation regarding the function of the dentate gyrus (DG)—
a subregion of the mammalian hippocampus—in learning and memory. In this Perspective …

Microglia originate from yolk sac-primitive macrophages and auto-proliferate into adulthood
without replacement by bone marrow-derived circulating cells. In inflammation, stroke …

The extent to which neurogenesis occurs in adult primates remains controversial. In this
study, using an optimized single-cell RNA sequencing pipeline, we profiled 207,785 cells …

Adult hippocampal neurogenesis (AHN) represents a remarkable form of neuroplasticity that
has increasingly been linked to the stress response in recent years. However, the …

Physical exercise is well known as a non-pharmacological and holistic therapy believed to
prevent and mitigate numerous neurological conditions and alleviate ageing-related …

The brain undergoes ionizing radiation (IR) exposure in many clinical situations, particularly
during radiotherapy for malignant brain tumors. Cranial radiation therapy is related with the …

Abstract Background Zinc (Zn) has a diverse role in many biological processes, such as
growth, immunity, anti-oxidation system, homeostatic, and repairing. It acts as a regulatory …

Regular exercise induces a wide range of redox system-associated molecular adaptive
responses to the nervous system. The intermittent induction of reactive oxygen species …

The continuous generation of new neurons occurs in at least two well-defined niches in the
adult rodent brain. One of these areas is the subgranular zone of the dentate gyrus (DG) in …

Stem cells serve as a source of cellular material in embryogenesis and postnatal growth and
regeneration. This requires significant proliferative potential ensured by sufficient telomere …