Scleral structure and biomechanics

C Boote, IA Sigal, R Grytz, Y Hua, TD Nguyen… - Progress in retinal and …, 2020 - Elsevier
As the eye's main load-bearing connective tissue, the sclera is centrally important to vision.
In addition to cooperatively maintaining refractive status with the cornea, the sclera must …

A biomechanical paradigm for axonal insult within the optic nerve head in aging and glaucoma

CF Burgoyne - Experimental eye research, 2011 - Elsevier
This article is dedicated to Rosario Hernandez for her warm support of my own work and her
genuine enthusiasm for the work of her colleagues throughout her career. I first met Rosario …

Biomechanics of the optic nerve head

IA Sigal, CR Ethier - Experimental eye research, 2009 - Elsevier
Biomechanical factors acting at the level of the lamina cribrosa (LC) are postulated to play a
role in retinal ganglion cell dysfunction and loss in glaucoma. In support of this postulate, we …

Glaucomatous cupping of the lamina cribrosa: a review of the evidence for active progressive remodeling as a mechanism

JC Downs, MD Roberts, IA Sigal - Experimental eye research, 2011 - Elsevier
The purpose of this review is to examine the literature in an attempt to elucidate a
biomechanical basis for glaucomatous cupping. In particular, this work focuses on the role of …

Dimensions of the human sclera: thickness measurement and regional changes with axial length

RE Norman, JG Flanagan, SMK Rausch, IA Sigal… - Experimental eye …, 2010 - Elsevier
Scleral thickness, especially near the region of the optic nerve head (ONH), is a potential
factor of interest in the development of glaucomatous optic neuropathy. Our goal was to …

[HTML][HTML] Finite element analysis predicts large optic nerve head strains during horizontal eye movements

X Wang, H Rumpel, WEH Lim… - … & visual science, 2016 - jov.arvojournals.org
Purpose: We combined finite element (FE) analysis and dynamic magnetic resonance
imaging (MRI) to estimate optic nerve head (ONH) strains during horizontal eye movements …

Finite element modeling of the human sclera: influence on optic nerve head biomechanics and connections with glaucoma

RE Norman, JG Flanagan, IA Sigal, SMK Rausch… - Experimental eye …, 2011 - Elsevier
Scleral thickness, especially near the optic nerve head (ONH), is a potential factor of interest
in the development of glaucomatous optic neuropathy. Large differences in the dimensions …

Laminar and prelaminar tissue displacement during intraocular pressure elevation in glaucoma patients and healthy controls

Y Agoumi, GP Sharpe, DM Hutchison, MT Nicolela… - Ophthalmology, 2011 - Elsevier
OBJECTIVE: To determine the response of the anterior lamina cribrosa and prelaminar
tissue to acute elevation of intraocular pressure (IOP) in glaucoma patients and healthy …

In vivo evaluation of focal lamina cribrosa defects in glaucoma

S Kiumehr, SC Park, S Dorairaj, CC Teng… - Archives of …, 2012 - jamanetwork.com
Objectives To assess focal lamina cribrosa (LC) defects in glaucoma using enhanced depth
imaging optical coherence tomography and to investigate their spatial relationships with …

[HTML][HTML] Intraocular pressure, blood pressure, and retinal blood flow autoregulation: a mathematical model to clarify their relationship and clinical relevance

G Guidoboni, A Harris, S Cassani… - … & visual science, 2014 - jov.arvojournals.org
Purpose.: This study investigates the relationship between intraocular pressure (IOP) and
retinal hemodynamics and predicts how arterial blood pressure (BP) and blood flow …