Isolation and characterization of extracellular vesicle subpopulations from tissues

R Crescitelli, C Lässer, J Lötvall - Nature protocols, 2021 - nature.com
Extracellular vesicles (EVs) are lipid bilayered membrane structures released by all cells.
Most EV studies have been performed by using cell lines or body fluids, but the number of …

Tissue‐derived extracellular vesicles in cancers and non‐cancer diseases: present and future

SR Li, QW Man, X Gao, H Lin, J Wang… - Journal of …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are lipid‐bilayer membrane structures secreted by most cell
types. EVs act as messengers via the horizontal transfer of lipids, proteins, and nucleic …

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

JA Welsh, DCI Goberdhan, L O'Driscoll… - Journal of …, 2024 - Wiley Online Library
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of
origin and change the functions and phenotypes of other cells. These features indicate …

Engineering extracellular vesicles by three‐dimensional dynamic culture of human mesenchymal stem cells

X Yuan, L Sun, R Jeske, D Nkosi… - Journal of …, 2022 - Wiley Online Library
Human mesenchymal stem cell (hMSC) derived extracellular vesicles (EVs) have shown
therapeutic potential in recent studies. However, the corresponding therapeutic components …

Tumor-targeted exosomes for delivery of anticancer drugs

R Raguraman, D Bhavsar, D Kim, X Ren, V Sikavitsas… - Cancer letters, 2023 - Elsevier
Exosomes are small phospholipid bilayer vesicles that are naturally produced by all living
cells, both prokaryotes and eukaryotes. The exosomes due to their unique size, reduced …

Matrix vesicles: role in bone mineralization and potential use as therapeutics

S Ansari, BWM de Wildt, MAM Vis, CE de Korte, K Ito… - Pharmaceuticals, 2021 - mdpi.com
Bone is a complex organ maintained by three main cell types: osteoblasts, osteoclasts, and
osteocytes. During bone formation, osteoblasts deposit a mineralized organic matrix …

Exosomes as a drug delivery tool for cancer therapy: A new era for existing drugs and oncolytic viruses

Y Kakiuchi, S Kuroda, N Kanaya… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Exosomes are cell-derived nanovesicles involved in cell-to-cell
communications. These nanovesicles are generally considered to contain important carriers …

Microglia‐derived extracellular vesicles in homeostasis and demyelination/remyelination processes

VSB Wies Mancini, VS Mattera… - Journal of …, 2024 - Wiley Online Library
Microglia (MG) play a crucial role as the predominant myeloid cells in the central nervous
system and are commonly activated in multiple sclerosis. They perform essential functions …

Mechanisms and biomarker potential of extracellular vesicles in stroke

N Ollen-Bittle, AD Roseborough, W Wang, JD Wu… - Biology, 2022 - mdpi.com
Simple Summary A stroke occurs when there is a lack of blood flow to the brain. Stroke
injures the brain and can have devastating outcomes depending on the size and location of …

[HTML][HTML] Extracellular vesicle signalling in atherosclerosis

E Charla, J Mercer, P Maffia, SA Nicklin - Cellular signalling, 2020 - Elsevier
Atherosclerosis is a major cardiovascular disease and in 2016, the World Health
Organisation (WHO) estimated 17.5 million global deaths, corresponding to 31% of all …