Recent advancements in the creation of artificial extra base pairs (unnatural base pairs,
UBPs) are opening the door to a new research area, xenobiology, and genetic alphabet …

The introduction of chemical modifications into long RNA molecules at specific positions for
visualization, biophysical investigations, diagnostic and therapeutic applications still …

Development of unnatural base pairs (UBPs) has significantly expanded the genetic
alphabet both in vitro and in vivo and led to numerous potential applications in the …

To understand how RNA dynamics is regulated and connected to its function, we investigate
the folding, conformational dynamics and robustness of Xrn1 resistance of a set of flaviviral …

We present herein a novel nitroxide spin label‐containing RNA triphosphate TPT3NO and
its application for site‐specific spin‐labeling of RNA through in vitro transcription using an …

Highlights•Modified nucleotides stabilize and increase the potential functions of DNA and
RNA.•Modified nucleotides allow DNA and RNA to adopt protein-like structures.• …

Cellular protein-RNA complexes assemble on nascent transcripts, but methods to observe
transcription and protein binding in real time and at physiological concentrations are not …

Exciting new technological developments have pushed the boundaries of structural biology,
and have enabled studies of biological macromolecules and assemblies that would have …

Nucleic acids underlie the storage and retrieval of genetic information literally in all living
organisms, and also provide us excellent materials for making artificial nanostructures and …

The development of novel bioorthogonal reagents for biological applications has increased
considerably in the last decade. Of these tools, the modification of biological entities by …