Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD),
food allergy (FA), and eczema are systemic diseases caused by an impaired immune …

Inflammasomes are key signalling platforms that detect pathogenic microorganisms and
sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL …

Inflammasomes are multiprotein complexes that function as sensors of endogenous or
exogenous damage-associated molecular patterns. Here, we show that deficiency of NLRP6 …

Innate immune responses have the ability to both combat infectious microbes and drive
pathological inflammation. Inflammasome complexes are a central component of these …

Pyroptosis is a form of programmed cell death activated by various stimuli and is
characterized by inflammasome assembly, membrane pore formation, and the secretion of …

In addition to high-fat diet (HFD) and inactivity, inflammation and microbiota composition
contribute to obesity. Inhibitory immune receptors, such as NLRP12, dampen inflammation …

Nucleotide-binding and oligomerization domain NOD-like receptors (NLRs) are highly
conserved cytosolic pattern recognition receptors that perform critical functions in surveying …

Background The mouse inbred line C57BL/6J is widely used in mouse genetics and its
genome has been incorporated into many genetic reference populations. More recently …

Inflammasomes are cytosolic multiprotein complexes that assemble in response to a variety
of infectious and noxious insults. Inflammasomes play a critical role in the initiation of innate …

In vitro data suggest that a subgroup of NLR proteins, including NLRP12, inhibits the
transcription factor NF-κB, although physiologic and disease-relevant evidence is largely …