Nuclear pregnane X receptor (PXR, NR1I2) and constitutive active/androstane receptor
(CAR, NR1I3) are nuclear receptors characterized in 1998 by their capability to respond to …

Estrogen sulfotransferase (SULT1E1) is a phase II enzyme that sulfates estrogens to
inactivate them and regulate their homeostasis. This enzyme is also involved in the sulfation …

Nuclear receptors (NR) collectively regulate several biological functions in various organs.
While NRs can be characterized by activation of the transcription of their signature genes …

Abstract Ethnopharmacological relevance Salt-processed Psoraleae fructus (SPF) is widely
used as a phytoestrogen-like agent in the treatment of osteoporosis. However, SPF …

Circulating estrogens levels significantly decrease in menopause and levels off in
postmenopausal women. Accordingly, the liver represses levels of enzymes and membrane …

Hepatic estrogen sulfotransferase (SULT1E1), the enzyme that inactivates estrogen,
regulates metabolic estrogen homeostasis. Here, we have demonstrated how nuclear …

Dichlorodiphenyltrichloroethane (DDT) is an organochlorine insecticide used worldwide.
Several studies have reported the toxic effects of DDT and its metabolites on steroid …

Testicular steroids can alter the activity and expression of enzymes within the liver and may
influence the metabolism of skatole and androstenone, which are responsible for boar taint …

Many factors cause interperson variability in the activity and expression of the cytochrome
P450 (CYP) drug-metabolizing enzymes in the liver, leading to variable drug exposure and …

Diabetes mellitus (DM) is a major metabolic disorder and an increasing health problem
worldwide. Effective non-invasive therapies for DM are still lacking. Here, we have …