The identification of cathepsins in amyloid-β plaques revealed broad dysfunction of the
lysosomal system in Alzheimer's disease (AD). Coinciding with the discovery that proteolysis …

Neurodegeneration occurs in acute pathological conditions such as stroke, ischemia, and
head trauma and in chronic disorders such as Alzheimer's disease, Parkinson's disease …

The use of human mesenchymal stem cells (hMSCs) has emerged as a possible therapeutic
strategy for CNS-related conditions. Research in the last decade strongly suggests that MSC …

DJ-1 has recently been shown to be responsible for onset of familial Parkinson's disease
(PD), PARK7. DJ-1 has been shown to play roles in transcriptional regulation and anti …

Abstract Cystatin C (CYS C, Cst3) is an endogenous cysteine protease inhibitor that plays
neuroprotective roles in neurodegenerative diseases. We aimed to explore the association …

Amyotrophic lateral sclerosis (ALS) is a fatal neurologic disease characterized by
progressive motor neuron degeneration. Clinical disease management is hindered by both …

Background Moderate and late preterm (MLPT) birth accounts for the vast majority of
preterm births, which is a global public health problem. The association between MLPT and …

Increased proteolytic activity is a hallmark of several pathological processes, including
neurodegeneration. Increased expression and activity of cathepsins, lysosomal cysteine …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the selective and progressive loss of motor neurons. Cystatin C (CysC), an endogenous …

Astrocytes, one of the predominant types of glial cells, function as both supportive and
metabolic cells for the brain. Under cerebral ischemia/reperfusion‐induced oxidative …