E3 ligases: a ubiquitous link between DNA repair, DNA replication and human disease

AS Chauhan, SS Jhujh, GS Stewart - Biochemical Journal, 2024 - portlandpress.com
Maintenance of genome stability is of paramount importance for the survival of an organism.
However, genomic integrity is constantly being challenged by various endogenous and …

Pin1-Catalyzed Conformation Changes Regulate Protein Ubiquitination and Degradation

J Jeong, M Usman, Y Li, XZ Zhou, KP Lu - Cells, 2024 - mdpi.com
The unique prolyl isomerase Pin1 binds to and catalyzes cis–trans conformational changes
of specific Ser/Thr-Pro motifs after phosphorylation, thereby playing a pivotal role in …