The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Fat accumulation outside subcutaneous adipose tissue often has unfavourable effects on
systemic metabolism. In addition to non-alcoholic fatty liver disease, which has received …

Background Type 2 diabetes (T2D) is a heterogeneous disease for which (1) disease-
causing pathways are incompletely understood and (2) subclassification may improve …

OBJECTIVE: This article examines the foundation of β-cell failure in type 2 diabetes (T2D)
and suggests areas for future research on the underlying mechanisms that may lead to …

Type 2 diabetes (T2D) is a complex disease that is caused by a complex interplay between
genetic, epigenetic and environmental factors. While the major environmental factors, diet …

Impaired insulin secretion is a hallmark of type 2 diabetes (T2D). Epigenetics may affect
disease susceptibility. To describe the human methylome in pancreatic islets and determine …

Pancreatic β cells secrete insulin, the body's only hormone capable of lowering plasma
glucose levels. Impaired or insufficient insulin secretion results in diabetes mellitus. The β …

The inability of pancreatic β-cells to make sufficient insulin to control blood sugar is a central
feature of the aetiology of most forms of diabetes. In this review we focus on the deleterious …

Type 2 diabetes (T2D) is caused by insufficient insulin secretion from pancreatic β cells. To
identify candidate genes contributing to T2D pathophysiology, we studied human pancreatic …

Abstract Type 2 diabetes (T2D) mellitus has emerged as a major global health concern that
has accelerated in recent years due to poor diet and lifestyle. Afflicted individuals have high …