Introduction: Respiratory drug delivery is a surprisingly complex process with a number of
physical and biological challenges. Computational fluid dynamics (CFD) is a scientific …

Nebulizers have a number of advantages for the delivery of inhaled pharmaceutical
aerosols, including the use of aqueous formulations and the ability to deliver process …

Aerosol therapy in infants and toddlers is challenging. Nebulization within a nasal high flow
(NHF) circuit is attractive. The aim of this study was to quantify aerosol lung deposition when …

Aerosolized administration of biopharmaceuticals to the airways is a promising route for
nasal and pulmonary drug delivery, but− in contrast to small molecules− little is known about …

While dry powder aerosol formulations offer a number of advantages, their use in children is
often limited due to poor lung delivery efficiency and difficulties with consistent dry powder …

High-flow nasal cannula (HFNC) therapy is an oxygen delivery method particularly used in
patients affected by hypoxemic respiratory failure. In comparison with the conventional “low …

Purpose The objective of this study was to evaluate the delivery of nasally administered
aerosols to the lungs during noninvasive ventilation using controlled condensational growth …

Inhaled medications are the mainstay of therapy for many pediatric pulmonary diseases.
Device and delivery technique selection is key to improving lung deposition of inhaled …

Background: Computational fluid dynamics (CFD) provides a powerful tool for developing
new high-efficiency aerosol delivery strategies, such as nose-to-lung (N2L) aerosol …

Pharmaceutical aerosol systems present a significant challenge to computational fluid
dynamics (CFD) modeling based on the need to capture multiple levels of turbulence …