CTLA-4: a moving target in immunotherapy

B Rowshanravan, N Halliday… - Blood, The Journal of …, 2018 - ashpublications.org
CD28 and CTLA-4 are members of a family of immunoglobulin-related receptors that are
responsible for various aspects of T-cell immune regulation. The family includes CD28 …

Inflammation and immune cell abnormalities in intracranial aneurysm subarachnoid hemorrhage (SAH): relevant signaling pathways and therapeutic strategies

J Jin, J Duan, L Du, W Xing, X Peng… - Frontiers in …, 2022 - frontiersin.org
Intracranial aneurysm subarachnoid hemorrhage (SAH) is a cerebrovascular disorder
associated with high overall mortality. Currently, the underlying mechanisms of pathological …

Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell–derived lymphomas

D Vallois, MPD Dobay, RD Morin… - Blood, The Journal …, 2016 - ashpublications.org
Angioimmunoblastic T-cell lymphoma (AITL) and other lymphomas derived from follicular T-
helper cells (TFH) represent a large proportion of peripheral T-cell lymphomas (PTCLs) with …

Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T-cell lymphoma

TB Heavican, A Bouska, J Yu, W Lone… - Blood, The Journal …, 2019 - ashpublications.org
Peripheral T-cell lymphoma (PTCL) is a group of complex clinicopathological entities, often
associated with an aggressive clinical course. Angioimmunoblastic T-cell lymphoma (AITL) …

Peripheral T-cell lymphoma

FM Foss, PL Zinzani, JM Vose… - Blood, The Journal …, 2011 - ashpublications.org
Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of clinically aggressive
diseases associated with poor outcome. Studies that focus specifically on PTCL are …

Peripheral T cell lymphomas: from the bench to the clinic

D Fiore, LV Cappelli, A Broccoli, PL Zinzani… - Nature Reviews …, 2020 - nature.com
Peripheral T cell lymphomas (PTCLs) are a heterogeneous group of orphan neoplasms.
Despite the introduction of anthracycline-based chemotherapy protocols, with or without …

Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p. Q575E)

J Park, J Yang, AT Wenzel… - Blood, The Journal …, 2017 - ashpublications.org
Cutaneous T-cell lymphoma (CTCL) is an incurable non-Hodgkin lymphoma of the skin-
homing T cell. In early-stage disease, lesions are limited to the skin, but in later-stage …

DNMT3A mutations define a unique biological and prognostic subgroup associated with cytotoxic T cells in PTCL-NOS

TA Herek, A Bouska, W Lone, S Sharma… - Blood, The Journal …, 2022 - ashpublications.org
Peripheral T-cell lymphomas (PTCLs) are heterogenous T-cell neoplasms often associated
with epigenetic dysregulation. We investigated de novo DNA methyltransferase 3A …

Integrated mate-pair and RNA sequencing identifies novel, targetable gene fusions in peripheral T-cell lymphoma

RL Boddicker, GL Razidlo, S Dasari… - Blood, The Journal …, 2016 - ashpublications.org
Peripheral T-cell lymphomas (PTCLs) represent a heterogeneous group of T-cell
malignancies that generally demonstrate aggressive clinical behavior, often are refractory to …

Angioimmunoblastic T‐cell lymphoma contains multiple clonal T‐cell populations derived from a common TET2 mutant progenitor cell

WQ Yao, F Wu, W Zhang, SS Chuang… - The Journal of …, 2020 - Wiley Online Library
Angioimmunoblastic T‐cell lymphoma (AITL) is a neoplastic proliferation of T follicular
helper cells with clinical and histological presentations suggesting a role of antigenic drive …