Hundreds of microRNAs (miRNAs) are expressed in distinct spatial and temporal patterns
during embryonic and postnatal mouse development. The loss of all miRNAs through the …

Clustered regulatory interspaced short palindromic repeats (CRISPR) has changed
biomedical research and provided entirely new models to analyze every aspect of …

Definitive haematopoietic stem and progenitor cells (HSPCs) generate erythroid, lymphoid
and myeloid lineages. HSPCs are produced in the embryo via transdifferentiation of …

MicroRNAs (miRNAs) are small non-coding RNAs that play important roles in plant
development and stress responses. Loss-of-function analysis of miRNA genes has been …

Cerebral infarction/ischemia-reperfusion injury is currently the disease with the highest
mortality and disability rate of cardiovascular disease. Current studies have shown that …

Intracranial aneurysm (IA) rupture leads to subarachnoid hemorrhage, a sudden-onset
disease that often causes death or severe disability. Although genome-wide association …

Epigenetics classically refers to the inheritable changes of hereditary information without
perturbing DNA sequences. Understanding mechanisms of how epigenetic factors …

Cancer is characterized by multiple genetic and epigenetic alterations, including a higher
prevalence of mutations of oncogenes and/or tumor suppressors. Mounting evidences have …

MicroRNAs (miRs, miRNAs) are regulatory small noncoding RNAs, with their roles already
confirmed to be important for post-transcriptional regulation of gene expression affecting cell …

Anaplastic lymphoma kinase (Alk) and leucocyte tyrosine kinase (Ltk) were identified as
“orphan” receptor tyrosine kinases (RTKs) with oncogenic potential. Recently ALKAL1 and …