Interpreting the wealth of rare genetic variants discovered in population-scale sequencing
efforts and deciphering their associations with human health and disease present a critical …

In a human cell, thousands of replication forks simultaneously coordinate duplication of the
entire genome. The rate at which this process occurs might depend on the epigenetic state …

After reconstitution of nucleotide excision repair (excision repair) with XPA, RPA, XPC, TFIIH,
XPF-ERCC1 and XPG, it was concluded that these six factors are the minimal essential …

Abstract Aflatoxin B1 (AFB1), a potent mycotoxin, is one of the environmental risk factors that
cause liver cancer. In the liver, the bioactivated AFB1 intercalates into the DNA double helix …

Nephrotoxicity is the dose-limiting factor of cisplatin treatment. Magnesium isoglycyrrhizinate
(MgIG) has been reported to ameliorate renal ischemia–reperfusion injury. This study aimed …

Clickable nucleosides, most often 5-ethynyl-2′-deoxyuridine (EtU), are widely used in
studies of DNA replication in living cells and in DNA functionalization for bionanotechology …

The identification of sites of DNA replication initiation in mammalian cells has been
challenging. Here, we present unbiased detection of replication initiation events in human …

DNA damage compromises not only genome stability but also the integrity of the chromatin
template, which plays a central role in controlling cell identity. Our understanding of …

Simple Summary Several procedures have been developed to infer cell-cycle time and the
duration of the cycle phases, including tritiated thymidine autoradiography and the …

Nucleotide excision repair (NER) eliminates highly genotoxic solar UV-induced DNA
photoproducts that otherwise stimulate malignant melanoma development. Here, a genome …