Transfer and functional consequences of dietary microRNAs in vertebrates: concepts in search of corroboration: negative results challenge the hypothesis that dietary …

KW Witwer, KD Hirschi - Bioessays, 2014 - Wiley Online Library
If validated, diet‐derived foreign microRNA absorption and function in consuming
vertebrates would drastically alter our understanding of nutrition and ecology. RNA …

Proteogenomics: integrating next-generation sequencing and mass spectrometry to characterize human proteomic variation

GM Sheynkman, MR Shortreed… - Annual review of …, 2016 - annualreviews.org
Mass spectrometry–based proteomics has emerged as the leading method for detection,
quantification, and characterization of proteins. Nearly all proteomic workflows rely on …

Alternative splicing of mutually exclusive exons—A review

M Pohl, RH Bortfeldt, K Grützmann, S Schuster - Biosystems, 2013 - Elsevier
Alternative splicing (AS) of pre-mRNAs in higher eukaryotes and several viruses is one
major source of protein diversity. Usually, the following major subtypes of AS are …

mRNA changes in nucleus accumbens related to methamphetamine addiction in mice

L Zhu, J Li, N Dong, F Guan, Y Liu, D Ma, ELK Goh… - Scientific reports, 2016 - nature.com
Methamphetamine (METH) is a highly addictive psychostimulant that elicits aberrant
changes in the expression of microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in …

Alternative splicing for diseases, cancers, drugs, and databases

JY Tang, JC Lee, MF Hou, CL Wang… - The Scientific World …, 2013 - Wiley Online Library
Alternative splicing is a major diversification mechanism in the human transcriptome and
proteome. Several diseases, including cancers, have been associated with dysregulation of …

Splicing Express: a software suite for alternative splicing analysis using next-generation sequencing data

JE Kroll, J Kim, L Ohno-Machado, SJ de Souza - PeerJ, 2015 - peerj.com
Motivation. Alternative splicing events (ASEs) are prevalent in the transcriptome of
eukaryotic species and are known to influence many biological phenomena. The …

A tool for integrating genetic and mass spectrometry‐based peptide data: Proteogenomics Viewer: PV: A genome browser‐like tool, which includes MS data …

JE Kroll, VL da Silva, SJ de Souza, GA de Souza - Bioessays, 2017 - Wiley Online Library
In this manuscript we describe Proteogenomics Viewer, a web‐based tool that collects MS
peptide identification, indexes to genomic sequence and structure, assigns exon usage …

Identification of rare alternative splicing events in MS/MS data reveals a significant fraction of alternative translation initiation sites

JE Kroll, SJ de Souza, GA de Souza - PeerJ, 2014 - peerj.com
Integration of transcriptome data is a crucial step for the identification of rare protein variants
in mass-spectrometry (MS) data with important consequences for all branches of …

Identifying splicing regulatory elements with de Bruijn graphs

E Badr, LS Heath - Journal of Computational Biology, 2014 - liebertpub.com
Splicing regulatory elements (SREs) are short, degenerate sequences on pre-mRNA
molecules that enhance or inhibit the splicing process via the binding of splicing factors …

Alternative splicing and cancer

JE Kroll, AF Fonseca… - Post-genomic Approaches …, 2022 - api.taylorfrancis.com
Next-generation sequencing is allowing an exhaustive exploration of the complexity of the
human transcriptome through RNA-Seqtechnologies [1, 2]. What would be a dream ten …