Western diet: implications for brain function and behavior

I López-Taboada, H González-Pardo… - Frontiers in …, 2020 - frontiersin.org
The Western diet (WD) pattern characterized by high daily intake of saturated fats and
refined carbohydrates often leads to obesity and overweight, and it has been linked to …

Glycolytic metabolism, brain resilience, and Alzheimer's disease

X Zhang, N Alshakhshir, L Zhao - Frontiers in Neuroscience, 2021 - frontiersin.org
Alzheimer's disease (AD) is the most common form of age-related dementia. Despite
decades of research, the etiology and pathogenesis of AD are not well understood. Brain …

Intake of flavonoids from Astragalus membranaceus ameliorated brain impairment in diabetic mice via modulating brain-gut axis

X Li, T Zhao, J Gu, Z Wang, J Lin, R Wang, T Duan… - Chinese medicine, 2022 - Springer
Background Brain impairment is one of a major complication of diabetes. Dietary flavonoids
have been recommended to prevent brain damage. Astragalus membranaceus is a herbal …

Bidirectional interactions between diabetes and Alzheimer's disease

M Shinohara, N Sato - Neurochemistry International, 2017 - Elsevier
Clinical studies have indicated that diabetes is associated with Alzheimer's disease (AD)
and neurodegeneration. However, the mechanisms underlying this association have not …

Pathological mechanisms linking diabetes mellitus and Alzheimer's disease: The receptor for advanced glycation end products (RAGE)

Y Kong, F Wang, J Wang, C Liu, Y Zhou… - Frontiers in aging …, 2020 - frontiersin.org
Diabetes and Alzheimer's disease (AD) place a significant burden on health care systems in
the world and its aging populations. These diseases have long been regarded as separate …

Diabetes: Risk factor and translational therapeutic implications for Alzheimer's disease

J Cummings, A Ortiz, J Castellino… - European Journal of …, 2022 - Wiley Online Library
Type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD) commonly co‐occur. T2DM
increases the risk for AD by approximately twofold. Animal models provide one means of …

[HTML][HTML] Telomerase gene therapy ameliorates the effects of neurodegeneration associated to short telomeres in mice

K Whittemore, A Derevyanko, P Martinez… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Neurodegenerative diseases associated with old age such as Alzheimer's disease present
major problems for society, and they currently have no cure. The telomere protective caps at …

Evidence for altered insulin receptor signaling in Alzheimer's disease

CM Griffith, T Eid, GM Rose, PR Patrylo - Neuropharmacology, 2018 - Elsevier
Epidemiological data have shown that metabolic disease can increase the propensity for
developing cognitive decline and dementia, particularly Alzheimer's disease (AD). While this …

Crucial players in Alzheimer's disease and diabetes mellitus: friends or foes?

AM Kubis-Kubiak, A Rorbach-Dolata… - Mechanisms of Ageing …, 2019 - Elsevier
Alzheimer's disease (AD) and diabetes mellitus, especially type 2 (T2DM), are very common
and widespread diseases in contemporary societies, and their incidence is steadily on the …

Linking diabetes to Alzheimer's disease: potential roles of glucose metabolism and alpha-glucosidase

AS Wee, TD Nhu, KY Khaw, KS Tang… - Current …, 2023 - benthamdirect.com
Alzheimer's disease (AD) and type 2 diabetes mellitus (DM) are more prevalent with ageing
and cause a substantial global socio-economic burden. The biology of these two conditions …