Environments experienced by organisms during early development shape the character and
timing of developmental processes, leading to different probabilities of survival in the …

Krüppel-like factors (KLFs) are a family of zinc-finger transcription factors that are found in
many species. Recent studies have shown that KLFs play a fundamental role in regulating …

Human pluripotent stem cells (hPSCs) have the potential to generate any human cell type,
and one widely recognized goal is to make pancreatic β cells. To this end, comparisons …

Reactive oxygen species (ROS) activate NF-E2-related transcription factor 2 (Nrf2), a key
transcriptional regulator driving antioxidant gene expression and protection from oxidant …

Chronic glucocorticoid therapy has serious side effects, including diabetes and fatty liver.
However, the molecular mechanisms responsible for steroid-induced diabetes remain …

The study of the causes and mechanisms underlying psychiatric disorders requires the use
of non-human models for the test of scientific hypotheses as well as for use in pre-clinical …

Understanding axon regenerative failure remains a major goal in neuroscience, and
reversing this failure remains a major goal for clinical neurology. Although an inhibitory …

The environment experienced by developing organisms can shape the timing and character
of developmental processes, generating different phenotypes from the same genotype, each …

Neurons in the adult mammalian CNS decrease in intrinsic axon growth capacity during
development in concert with changes in Krüppel-like transcription factors (KLFs). KLFs …

Hypothyroidism is a well-described cause of hypomyelination. In addition, thyroid hormone
(T3) has recently been shown to enhance remyelination in various animal models of CNS …