In the human eye, a transparent cornea and lens combine to form the" refracton" to focus
images on the retina. This requires the refracton to have a high refractive index" n," mediated …

Background The two α-crystallins (αA-and αB-crystallin) are major components of our eye
lenses. Their key function there is to preserve lens transparency which is a challenging task …

Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

In human lens proteins, advanced glycation endproducts (AGEs) originate from the reaction
of glycating agents, eg, vitamin C and glucose. AGEs have been considered to play a …

α-Crystallin is a member of the small heat-shock protein (sHSP) family and consists of two
subunits, αA and αB. Both αA-and αB-crystallin act as chaperones and anti-apoptotic …

The ocular lens is a unique tissue that contains an age gradient of cells and proteins ranging
from newly differentiated cells containing newly synthesized proteins to cells and proteins …

Cataract is a major cause of blindness. Due to the lack of protein turnover, lens proteins
accumulate age-related and environmental modifications that alter their native conformation …

Aging proteins in the lens become increasingly aggregated and insoluble, contributing to
presbyopia. In this study, we investigated the ability of aggrelyte‐2 (N, S‐diacetyl‐L‐cysteine …

With aging, human lenses lose the ability to focus on nearby objects due to decreases in
accommodative ability, a condition known as presbyopia. An increase in stiffness or …

In addition to their key role as structural lens proteins, α-crystallins also appear to confer
protection against many eye diseases, including cataract, retinitis pigmentosa, and macular …