Cellular and engineered organoids for cardiovascular models
An ensemble of in vitro cardiac tissue models has been developed over the past several
decades to aid our understanding of complex cardiovascular disorders using a reductionist …
decades to aid our understanding of complex cardiovascular disorders using a reductionist …
Arrhythmias as presentation of genetic cardiomyopathy
J Lukas Laws, MC Lancaster… - Circulation …, 2022 - Am Heart Assoc
There is increasing evidence regarding the prevalence of genetic cardiomyopathies, for
which arrhythmias may be the first presentation. Ventricular and atrial arrhythmias …
which arrhythmias may be the first presentation. Ventricular and atrial arrhythmias …
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
While many diseases of aging have been linked to the immunological system, immune
metrics capable of identifying the most at-risk individuals are lacking. From the blood …
metrics capable of identifying the most at-risk individuals are lacking. From the blood …
SGLT2 inhibitor ameliorates endothelial dysfunction associated with the common ALDH2 alcohol flushing variant
The common aldehyde dehydrogenase 2 (ALDH2) alcohol flushing variant known as
ALDH2* 2 affects∼ 8% of the world's population. Even in heterozygous carriers, this …
ALDH2* 2 affects∼ 8% of the world's population. Even in heterozygous carriers, this …
Lamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiovascular cell fate and function
Y Wang, A Elsherbiny, L Kessler, J Cordero… - Nature …, 2022 - nature.com
Tight control of cell fate choices is crucial for normal development. Here we show that lamin
A/C plays a key role in chromatin organization in embryonic stem cells (ESCs), which …
A/C plays a key role in chromatin organization in embryonic stem cells (ESCs), which …
Next-Gen therapeutics: Pioneering drug discovery with iPSCs, genomics, AI, and clinical trials in a dish
In the high-stakes arena of drug discovery, the journey from bench to bedside is hindered by
a daunting 92% failure rate, primarily due to unpredicted toxicities and inadequate …
a daunting 92% failure rate, primarily due to unpredicted toxicities and inadequate …
A call to action for new global approaches to cardiovascular disease drug solutions
GA Figtree, K Broadfoot, B Casadei, R Califf… - European heart …, 2021 - academic.oup.com
Whilst we continue to wrestle with the immense challenge of implementing equitable access
to established evidence-based treatments, substantial gaps remain in our pharmacotherapy …
to established evidence-based treatments, substantial gaps remain in our pharmacotherapy …
Statins improve endothelial function via suppression of epigenetic-driven EndMT
The pleiotropic benefits of statins in cardiovascular diseases that are independent of their
lipid-lowering effects have been well documented, but the underlying mechanisms remain …
lipid-lowering effects have been well documented, but the underlying mechanisms remain …
Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure …
Genetic cardiomyopathies are disorders of the cardiac muscle, most often explained by
pathogenic mutations in genes encoding sarcomere, cytoskeleton, or ion channel proteins …
pathogenic mutations in genes encoding sarcomere, cytoskeleton, or ion channel proteins …
FDA modernization act 2.0 paves the way to computational biology and clinical trials in a dish
The evaluation of drug safety and efficacy is an expensive, time-consuming process with a
high failure rate. Animal testing was the only nonhuman testing method to assess drug …
high failure rate. Animal testing was the only nonhuman testing method to assess drug …