Plight of CORMs: The unreliability of four commercially available CO-releasing molecules, CORM-2, CORM-3, CORM-A1, and CORM-401, in studying CO biology
Carbon monoxide (CO) is an endogenously produced gaseous signaling molecule with
demonstrated pharmacological effects. In studying CO biology, three delivery forms have …
demonstrated pharmacological effects. In studying CO biology, three delivery forms have …
Carbon monoxide signaling: examining its engagement with various molecular targets in the context of binding affinity, concentration, and biologic response
Carbon monoxide (CO) has been firmly established as an endogenous signaling molecule
with a variety of pathophysiological and pharmacological functions, including …
with a variety of pathophysiological and pharmacological functions, including …
External stimuli-responsive gasotransmitter prodrugs: Chemistry and spatiotemporal release
Gasotransmitters like nitric oxide, carbon monoxide, and hydrogen sulfide with unique
pleiotropic pharmacological effects in mammals are an emerging therapeutic modality for …
pleiotropic pharmacological effects in mammals are an emerging therapeutic modality for …
Role of carbon monoxide in host–gut microbiome communication
CP Hopper, LK De La Cruz, KV Lyles… - Chemical …, 2020 - ACS Publications
Nature is full of examples of symbiotic relationships. The critical symbiotic relation between
host and mutualistic bacteria is attracting increasing attention to the degree that the gut …
host and mutualistic bacteria is attracting increasing attention to the degree that the gut …
[HTML][HTML] Click chemistry and drug delivery: A bird's-eye view
Click chemistry has been proven to be very useful in drug delivery. Due to the availability of
a large number of click reactions with a various characteristics, selection of appropriate …
a large number of click reactions with a various characteristics, selection of appropriate …
On-demand therapeutic delivery of hydrogen sulfide aided by biomolecules
Y Ge, F Rong, W Li, Y Wang - Journal of Controlled Release, 2022 - Elsevier
Abstract Hydrogen sulfide (H 2 S), known as the third gasotransmitter, exerts various
physiological functions including cardiac protection, angiogenesis, anti-inflammatory, and …
physiological functions including cardiac protection, angiogenesis, anti-inflammatory, and …
Reactive oxygen species-activated metal-free carbon monoxide prodrugs for targeted cancer treatment
Z Li, Y Wang, M Liu, Y Pan, Z Ni, Q Min… - Journal of Medicinal …, 2023 - ACS Publications
Carbon monoxide has shown promise as a therapeutic agent against cancers. Reactive
oxygen species (ROS)-activated CO prodrugs are highly demanded for targeted cancer …
oxygen species (ROS)-activated CO prodrugs are highly demanded for targeted cancer …
“CO in a pill”: Towards oral delivery of carbon monoxide for therapeutic applications
Along with the impressive achievements in understanding the endogenous signaling roles
and mechanism (s) of action of carbon monoxide (CO), much research has demonstrated …
and mechanism (s) of action of carbon monoxide (CO), much research has demonstrated …
A brief history of carbon monoxide and its therapeutic origins
CP Hopper, PN Zambrana, U Goebel, J Wollborn - Nitric Oxide, 2021 - Elsevier
It is estimated that 10% of carbon throughout the cosmos is in the form of carbon monoxide
(CO). Earth's earliest prebiotic atmosphere included the trinity of gasotransmitters CO, nitric …
(CO). Earth's earliest prebiotic atmosphere included the trinity of gasotransmitters CO, nitric …
[HTML][HTML] Nature's marvels endowed in gaseous molecules I: carbon monoxide and its physiological and therapeutic roles
Nature has endowed gaseous molecules such as O 2, CO 2, CO, NO, H 2 S, and N 2 with
critical and diverse roles in sustaining life, from supplying energy needed to power life and …
critical and diverse roles in sustaining life, from supplying energy needed to power life and …