Sepsis is the life-threatening organ dysfunction caused by a dysregulated host response to
infection and is the leading cause of death in intensive care units. Cardiac dysfunction …

Importance Survival from sepsis has improved in recent years, resulting in an increasing
number of patients who have survived sepsis treatment. Current sepsis guidelines do not …

Objectives: To describe, with an emphasis on clinical applications, what is known about the
pathophysiology, management, and implications of septic cardiomyopathy in the adult ICU …

Objective To identify research priorities in the management, epidemiology, outcome and
underlying causes of sepsis and septic shock. Design A consensus committee of 16 …

Objectives: To provide an appraisal of the evolving paradigms in the pathophysiology of
sepsis and propose the evolution of a new phenotype of critically ill patients, its potential …

Pneumonia is a type of acute lower respiratory infection that is common and severe. The
outcome of lower respiratory infection is determined by the degrees to which immunity is …

Background Intensive care unit (ICU) survivors have reduced long-term survival compared
to the general population. Identifying parameters at ICU discharge that are associated with …

Rationale: Patients with sepsis who survive to hospital discharge may present with ongoing
high morbidity and mortality. However, little is known about the risk of long-term, all-cause …

Importance Long-term immune sequelae after sepsis are poorly understood. Objective To
assess whether abnormalities in the host immune response during hospitalization for sepsis …

Sepsis is life-threating organ dysfunction due to infection. Incidence of sepsis is increasing
and the short-term mortality is improving, generating more sepsis survivors. These sepsis …