The application and integration of molecular profiling technologies create novel
opportunities for personalized medicine. Here, we introduce the Tumor Profiler Study, an …

Precision oncology is a rapidly evolving interdisciplinary medical specialty. Comprehensive
cancer panels are becoming increasingly available at pathology departments worldwide …

Objectives Tumor biomarker analyses accompanying immuno-oncology therapies are
coupled with a tumor tissue journey aiming to guide tissue procurement and allow for …

Background Colon cancer is common worldwide and is the leading cause of cancer-related
death. Multiple levels of omics data are available due to the development of sequencing …

Motivation Identification and interpretation of clinically actionable variants is a critical
bottleneck. Searching for evidence in the literature is mandatory according to …

Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful technique to decipher
tissue composition at the single-cell level and to inform on disease mechanisms, tumor …

PURPOSE Comprehensive targeted next-generation sequencing (NGS) panels are
routinely used in modern molecular cancer diagnostics. In molecular tumor boards, the …

Within recent years, many precision cancer medicine initiatives have been developed. Most
of these have focused on solid cancers, while the potential of precision medicine for patients …

Molecular tumor boards (MTBs) require specialized activities to leverage genomic data for
therapeutic decision-making. Currently, there are no defined standards for implementing …

Effective anti-tumor immunity is largely driven by cytotoxic CD8+ T cells that can specifically
recognize tumor antigens. However, the factors which ultimately dictate successful tumor …