Immune responses to human fungal pathogens and therapeutic prospects

MS Lionakis, RA Drummond, TM Hohl - Nature Reviews Immunology, 2023 - nature.com
Pathogenic fungi have emerged as significant causes of infectious morbidity and death in
patients with acquired immunodeficiency conditions such as HIV/AIDS and following receipt …

Adjuvant physiochemistry and advanced nanotechnology for vaccine development

H Ren, W Jia, Y Xie, M Yu, Y Chen - Chemical Society Reviews, 2023 - pubs.rsc.org
Vaccines comprising innovative adjuvants are rapidly reaching advanced translational
stages, such as the authorized nanotechnology adjuvants in mRNA vaccines against COVID …

The advances of adjuvants in mRNA vaccines

C Xie, R Yao, X Xia - npj Vaccines, 2023 - nature.com
The remarkable success of messenger RNA (mRNA) vaccines against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) has propelled the rapid development of …

Rewilding of laboratory mice enhances granulopoiesis and immunity through intestinal fungal colonization

YH Chen, F Yeung, KA Lacey, K Zaldana, JD Lin… - Science …, 2023 - science.org
The paucity of blood granulocyte populations such as neutrophils in laboratory mice is a
notable difference between this model organism and humans, but the cause of this species …

[HTML][HTML] Nanoformulations targeting immune cells for cancer therapy: mRNA therapeutics

W Yang, J Cao, H Cheng, L Chen, M Yu, Y Chen… - Bioactive Materials, 2023 - Elsevier
The approved worldwide use of two messenger RNA (mRNA) vaccines (BNT162b2 and
mRNA-1273) in late 2020 has proven the remarkable success of mRNA therapeutics …

[HTML][HTML] Resolving adjuvant mode of action to enhance vaccine efficacy

JL Turley, EC Lavelle - Current Opinion in Immunology, 2022 - Elsevier
Highlights•Adjuvants can be incorporated into vaccines to enhance the magnitude,
functionality, breadth and durability of antigen-specific immune responses.•A deeper …

Targeted cancer immunotherapy: nanoformulation engineering and clinical translation

M Yu, W Yang, W Yue, Y Chen - Advanced Science, 2022 - Wiley Online Library
With the rapid growth of advanced nanoengineering strategies, there are great implications
for therapeutic immunostimulators formulated in nanomaterials to combat cancer. It is crucial …

Histone demethylases in the regulation of immunity and inflammation

L Qu, T Yin, Y Zhao, W Lv, Z Liu, C Chen, K Liu… - Cell Death …, 2023 - nature.com
Pathogens or danger signals trigger the immune response. Moderate immune response
activation removes pathogens and avoids excessive inflammation and tissue damage …

Circular RNA vaccines with long-term lymph node-targeting delivery stability after lyophilization induce potent and persistent immune responses

J Wan, Z Wang, L Wang, L Wu, C Zhang, M Zhou… - Mbio, 2024 - Am Soc Microbiol
Several recent attempts to improve the stability and immunogenicity of messenger RNA
(mRNA) vaccines include the use of circular RNA (circRNA), targeted delivery, and …

Glycovaccinology: The design and engineering of carbohydrate-based vaccine components

SW Hulbert, P Desai, MC Jewett, MP DeLisa… - Biotechnology …, 2023 - Elsevier
Vaccines remain one of the most important pillars in preventative medicine, providing
protection against a wide array of diseases by inducing humoral and/or cellular immunity. Of …