Dying mammalian cells emit numerous signals that interact with the host to dictate the
immunological correlates of cellular stress and death. In the absence of reactive antigenic …

Eukaryotic initiation factor 2B, eIF2B is a guanine nucleotide exchange, factor with a central
role in coordinating the initiation of translation. During stress and disease, the activity of …

Recent studies have demonstrated immunologic dysfunction in severely ill coronavirus
disease 2019 (COVID-19) patients. We use single-cell RNA sequencing (scRNA-seq) to …

The identification of patients with coronavirus disease 2019 and high risk of severe disease
is a challenge in routine care. We performed cell phenotypic, serum, and RNA sequencing …

The integrated stress response (ISR) is activated by phosphorylation of the translation
initiation factor eIF2 in response to various stress conditions. Phosphorylated eIF2 (eIF2-P) …

Development of the messenger RNA (mRNA) vaccine has emerged as an effective and
speedy strategy to control the spread of new pathogens. After vaccination, the mRNA is …

Various stressors such as viral infection lead to the suppression of cap-dependent
translation and the activation of the integrated stress response (ISR), since the stress …

Viral infection triggers activation of the integrated stress response (ISR). In response to viral
double-stranded RNA (dsRNA), RNA-activated protein kinase (PKR) phosphorylates the …

Recent exciting studies have uncovered how membrane‐less organelles, also known as
biocondensates, are providing cells with rapid response pathways, allowing them to re …

The integrated stress response manifests with the phosphorylation of eukaryotic initiation
factor 2α (eIF2α) on serine residue 51 and plays a major role in the adaptation of cells to …