[HTML][HTML] Mammalian transient receptor potential TRPA1 channels: from structure to disease
K Talavera, JB Startek, J Alvarez-Collazo… - Physiological …, 2020 - journals.physiology.org
The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …
cation channels remarkably conserved through the animal kingdom. Mammals have only …
Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
Transient receptor potential (TRP) channels: a clinical perspective
Y Kaneko, A Szallasi - British journal of pharmacology, 2014 - Wiley Online Library
Transient receptor potential (TRP) channels are important mediators of sensory signals with
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …
Trpa1
PM Zygmunt, ED Högestätt - … potential (TRP) cation channels: volume I, 2014 - Springer
The transient receptor potential ankyrin subtype 1 protein (TRPA1) is a nonselective cation
channel permeable to Ca 2+, Na+, and K+. TRPA1 is a promiscuous chemical nocisensor …
channel permeable to Ca 2+, Na+, and K+. TRPA1 is a promiscuous chemical nocisensor …
TRPA1 antagonists for pain relief
A Koivisto, N Jalava, M Rantanen, H Chapman… - TRP Channels as …, 2024 - Elsevier
The topic of this chapter, transient receptor potential ankyrin 1 (TRPA1), is a calcium-
permeable nonselective cation channel that is a member of the TRP family expressed on …
permeable nonselective cation channel that is a member of the TRP family expressed on …
Transient receptor potential channels in sensory mechanisms of the lower urinary tract
M Vanneste, A Segal, T Voets, W Everaerts - Nature Reviews Urology, 2021 - nature.com
Disruptions to sensory pathways in the lower urinary tract commonly occur and can give rise
to lower urinary tract symptoms (LUTS). The unmet clinical need for treatment of LUTS has …
to lower urinary tract symptoms (LUTS). The unmet clinical need for treatment of LUTS has …
The protective effect of quercetin on cyclophosphamide-Induced lung toxicity in rats
Cyclophosphamide (CYP) is an anticancer agent widely used in chemotherapy. It has been
suggested that CYP causes toxicity in many organs, including the lungs and testes. Many …
suggested that CYP causes toxicity in many organs, including the lungs and testes. Many …
Inflammation—the role of TRPA1 channel
K Yao, B Dou, Y Zhang, Z Chen, Y Li, Z Fan… - Frontiers in …, 2023 - frontiersin.org
Recently, increasing numbers of studies have demonstrated that transient receptor potential
ankyrin 1 (TRPA1) can be used as a potential target for the treatment of inflammatory …
ankyrin 1 (TRPA1) can be used as a potential target for the treatment of inflammatory …
Characterization and validation of a chronic model of cyclophosphamide-induced interstitial cystitis/bladder pain syndrome in rats
C Augé, X Gamé, N Vergnolle, P Lluel… - Frontiers in …, 2020 - frontiersin.org
Interstitial cystitis/Bladder Pain Syndrome (IC/BPS) is a chronic inflammatory disease
characterized by visceral pain and voiding symptoms. IC/BPS is still an unsolved enigma …
characterized by visceral pain and voiding symptoms. IC/BPS is still an unsolved enigma …
TRP channels in nociception and pathological pain
CY Hung, CH Tan - Advances in pain research: mechanisms and …, 2018 - Springer
Thermal and noxious stimuli are detected by specialized nerve endings, which transform the
stimuli into electrical signals and transmit the signals into central nervous system to facilitate …
stimuli into electrical signals and transmit the signals into central nervous system to facilitate …