Simple Summary Breast cancer is the most common cancer affecting women under 40 years
of age worldwide, with an increasing number of cases diagnosed each year. Despite this …

The deoxyribonucleic acid (DNA) damage response (DDR) is a major feature in the
maintenance of genome integrity and in the suppression of tumorigenesis. PALB2 (Partner …

Inherited loss-of-function mutations in BRCA1 and BRCA2 and other tumor suppressor
genes predispose to ovarian carcinomas, but the overall burden of disease due to inherited …

Purpose Although the role of CHEK2 germline pathogenic variants in cancer predisposition
is well known, resources for managing CHEK2 heterozygotes in clinical practice are limited …

It is clear that FANCJ, also known as BACH1 or BRIP1, is an essential tumor suppressor
gene based on the identification of clinically relevant mutations not only in breast cancer, but …

Background Mutations in the BRCA1 and BRCA2 genes are responsible for only a part of
hereditary breast cancer (HBC). The origins of" non-BRCA" HBC in families may be …

Although the causes of prostate cancer are largely unknown, previous studies support the
role of genetic factors in the development of prostate cancer. CHEK2 plays a critical role in …

Breast cancer (BC) in young women, generally defined in oncology as women who are 40
years of age or younger, represents 2 out of 10 BC cases in developing countries. Several …

Germline mutations in the BRCA1 and BRCA2 genes are characterized by deficient repair of
DNA double-strand breaks by homologous recombination. Defective DNA double-strand …

Since germline mutations in the PALB2 (Partner and Localizer of BRCA2) gene have been
identified as breast cancer (BC) susceptibility alleles, the geographical spread and risks …