Hepatitis delta virus: insights into a peculiar pathogen and novel treatment options
Chronic hepatitis D is the most severe form of viral hepatitis, affecting∼ 20 million HBV-
infected people worldwide. The causative agent, hepatitis delta virus (HDV), is a unique …
infected people worldwide. The causative agent, hepatitis delta virus (HDV), is a unique …
RNA interference against viruses: strike and counterstrike
J Haasnoot, EM Westerhout, B Berkhout - Nature biotechnology, 2007 - nature.com
RNA interference (RNAi) is a conserved sequence-specific, gene-silencing mechanism that
is induced by double-stranded RNA. RNAi holds great promise as a novel nucleic acid …
is induced by double-stranded RNA. RNAi holds great promise as a novel nucleic acid …
miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and maydownregulate the high affinity cationic amino acid transporter CAT-1
These studies show that miR-122, a 22-nucleotide microRNA, is derived from a liver-
specificnon-coding polyadenylated RNA transcribed from the gene hcr. The exact sequence …
specificnon-coding polyadenylated RNA transcribed from the gene hcr. The exact sequence …
RNAi is an antiviral immune response against a dsRNA virus in Drosophila melanogaster
RA Zambon, VN Vakharia, LP Wu - Cellular microbiology, 2006 - Wiley Online Library
Drosophila melanogaster has a robust and efficient innate immune system, which reacts to
infections ranging from bacteria to fungi and, as discovered recently, viruses as well. The …
infections ranging from bacteria to fungi and, as discovered recently, viruses as well. The …
[HTML][HTML] New insights into HDV persistence: The role of interferon response and implications for upcoming novel therapies
Chronic hepatitis D (CHD), a global health problem, manifests as the most severe form of
viral hepatitis. The causative agent, hepatitis D virus (HDV), is the smallest known human …
viral hepatitis. The causative agent, hepatitis D virus (HDV), is the smallest known human …
Hepatitis D virus: an update
S Pascarella, F Negro - Liver International, 2011 - Wiley Online Library
Hepatitis D virus (HDV) infection involves a distinct subgroup of individuals simultaneously
infected with the hepatitis B virus (HBV) and characterized by an often severe chronic liver …
infected with the hepatitis B virus (HBV) and characterized by an often severe chronic liver …
Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs
SL Uprichard, B Boyd, A Althage… - Proceedings of the …, 2005 - National Acad Sciences
Hepatitis B virus (HBV) causes acute and chronic hepatitis and hepatocellular carcinoma.
Although a preventive vaccine is available, the therapeutic options for chronically infected …
Although a preventive vaccine is available, the therapeutic options for chronically infected …
[HTML][HTML] The therapeutic potential of RNA interference
SL Uprichard - FEBS letters, 2005 - Elsevier
In recent years, we have witnessed the discovery of a new mechanism of gene regulation
called RNA interference (RNAi), which has revitalized interest in the development of nucleic …
called RNA interference (RNAi), which has revitalized interest in the development of nucleic …
[HTML][HTML] Prolonged transcriptional silencing and CpG methylation induced by siRNAs targeted to the HIV-1 promoter region
K Suzuki, T Shijuuku, T Fukamachi… - Journal of RNAi and …, 2005 - ncbi.nlm.nih.gov
In addition to the degradation of homologous RNAs through the RNA interference (RNAi)
pathway, small interfering RNAs (siRNAs) can in some systems induce cytosine methylation …
pathway, small interfering RNAs (siRNAs) can in some systems induce cytosine methylation …
Structure and replication of hepatitis delta virus RNA
JM Taylor - Hepatitis delta virus, 2006 - Springer
Structure and replication of hepatitis delta virus RNA Page 28 CHAPTER 3 Structure and
Replication of Hepatitis Delta Virus RNA John M. Taylor* Abstract This review focuses on the …
Replication of Hepatitis Delta Virus RNA John M. Taylor* Abstract This review focuses on the …