Privileged structures have been widely used as an effective template for the research and
discovery of high value chemicals. Coumarin is a simple scaffold widespread in Nature and …

Carbonic anhydrases (CAs, EC 4.2. 1.1) catalyse the interconversion between CO2 and
bicarbonate as well as other hydrolytic reactions. Among the six genetic families known to …

Advances in the carbonic anhydrase (CA, EC 4.2. 1.1) research over the last three decades
are presented, with an emphasis on the deciphering of the activation mechanism, the …

Six genetic families of the enzyme carbonic anhydrase (CA, EC 4.2. 1.1) were described to
date. Inhibition of CAs has pharmacologic applications in the field of antiglaucoma …

Introduction: The enzyme carbonic anhydrase (CA, EC 4.2. 1.1) is found in numerous
organisms across the tree of life, with seven distinct classes known to date. CA inhibition can …

The tumor microenvironment is crucial for the growth of cancer cells, triggering particular
biochemical and physiological changes, which frequently influence the outcome of …

Carbonic anhydrases (CAs, EC 4.2. 1.1) are ubiquitous metallo-enzymes, present
throughout most living organisms and encoded by five evolutionarily unrelated gene …

The high metabolic rate of tumours often leads to acidosis and hypoxia in poorly perfused
regions. Tumour cells have thus evolved the ability to function in a more acidic environment …

Introduction Four different genetic families of the enzyme carbonic anhydrase (CA, EC 4.2.
1.1) are present in bacteria, α-, β-, γ-and ι-CAs. They play relevant functions related to CO2 …

Human carbonic anhydrase (CA) IX is a tumor‐associated protein, since it is scarcely
present in normal tissues, but highly overexpressed in a large number of solid tumors, where …