Abstract Superoxide dismutase 1 (SOD1) aggregation is implicated in the development of Amyotrophic Lateral Sclerosis (ALS). Despite knowledge of the role of SOD1 aggregation …
Protein misfolding is a biological process that leads to protein aggregation. Anomalous misfolding and aggregation of human superoxide dismutase (hSOD1) into amyloid …
P Nadalin, YG Kim, SU Park - EXCLI journal, 2023 - ncbi.nlm.nih.gov
Benzylisoquinoline alkaloids (BIAs) are a variety of plant chemicals that consist of roughly 2,500 known compounds. Many BIAs are characterized by potent pharmacological activities …
N Yuan, Y Chen, Y Yan, F Wang, X Xu, M Wang, J Diao… - Heliyon, 2024 - cell.com
Diabetic nephropathy (DN), a leading cause of end-stage renal disease, remains a formidable challenge in diabetes management due to the complex nature of its …
The idea of designing novel anti-amyloid therapeutic agents has generated a lot of scientific interest and the potential for treating a variety of human pathophysiologies, such as …