Transition metal-catalyzed cross-coupling reactions of organic electrophiles and
organometallic reagents have emerged as a tremendously powerful synthetic tool, and the …

Marine organisms have produced a big number of structurally diverse secondary
metabolites with important biological activities as a defense mechanism to the persistent …

Various chiral oxazolidinones (Evans' oxazolidinones) have been employed as effective
chiral auxiliaries in the asymmetric alkylation of different enolates. This strategy has been …

This review covers the recent results described in our publications on several new cytotoxic
macrolides isolated from dinoflagellates of the genus Amphidinium in addition to an …

Nature is a pretty unselective “chemist” when it comes to making the highly cytotoxic
amphidinolide macrolides of the B/G/H series. To date, 16 different such compounds have …

The fundamental role played by actin in the regulation of eukaryotic cell maintenance and
motility renders it a primary target for small-molecule intervention. In this arena, a class of …

The total synthesis of amphidinolide C and a second-generation synthesis of amphidinolide
F have been accomplished through the use of a common intermediate to access both the C1 …

Amphidinolides are a class of structurally rather unique macrolides of marine origin which
stimulated a lot of creative work in the total synthesis arena over the last decade. This review …

A new highly enantioselective domino Michael/hemiketalization reaction of α‐
hydroxyacetophenone with β, γ‐unsaturated α‐keto esters for the synthesis of 2, 2, 4, 5 …

The awesome power of metathesis is illustrated by a concise synthesis of the extremely
scarce marine natural product amphidinolide V, which hinges on a sequence of ring‐closing …