In the last decade, proteomics and metabolomics have contributed substantially to our
understanding of cardiovascular diseases. The unbiased assessment of pathophysiological …

Increased production of reactive oxygen species (ROS) as a result of decreased activities of
mitochondrial electron transport chain (ETC) complexes plays a role in the development of …

Despite conflicting evidence for the efficacy of hormone replacement therapy in
cardioprotection of postmenopausal women, numerous studies have demonstrated …

Abstract Aims: Mitochondrial supercomplexes (SCs) are the large supramolecular assembly
of individual electron transport chain (ETC) complexes that apparently provide highly …

Tissue proteomics is increasingly recognized for its role in biomarker discovery and disease
mechanism investigation. However, protein solubility remains a significant challenge in …

To achieve malignancy, cancer cells convert numerous signaling pathways, with evasion
from cell death being a characteristic hallmark. The cell death machinery represents an anti …

Abstract MitoMiner (http://mitominer. mrc-mbu. cam. ac. uk/) is a data warehouse for the
storage and analysis of mitochondrial proteomics data gathered from publications of mass …

Cellular phenotype is the conglomerate of multiple cellular processes involving gene and
protein expression that result in the elaboration of a cell's particular morphology and …

Mitochondrial functions are dynamically regulated in the heart. In particular, protein
phosphorylation has been shown to be a key mechanism modulating mitochondrial function …

Mitochondria are a common energy source for organs and organisms; their diverse functions
are specialized according to the unique phenotypes of their hosting environment …