Clinical neurophysiologic investigation of pain pathways in humans is based on specific
techniques and approaches, since conventional methods of nerve conduction studies and …

Monitoring nociceptive processing is a current challenge due to a lack of objective
measures. Recently, we developed a method for simultaneous tracking of psychophysical …

Measuring altered nociceptive processing involved in chronic pain is difficult due to a lack of
objective methods. Potential methods to characterize human nociceptive processing involve …

Sleep deprivation has been shown to increase pain intensity and decrease pain thresholds
in healthy subjects. In chronic pain patients, sleep impairment often worsens the perceived …

Pain disorders can be initiated and maintained by malfunctioning of one or several
mechanisms underlying the nociceptive function. Psychophysical procedures allow the …

Pain scientists and clinicians search for objective measures of altered nociceptive
processing to study and stratify chronic pain patients. Nociceptive processing can be studied …

Introduction Topical application of lidocaine‐and‐prilocaine (LP) cream attenuates the
functionality of small cutaneous nerve fibers. The aim of this human study was to measure …

Objectives There is a lack of clinically relevant measures for quantification of maladaptive
mechanisms of the nociceptive system leading to chronic pain. Recently, we developed a …

In behavioral and neurophysiological pain studies, multiple types of calibration methods are
used to quantify the individual pain sensation stimuli. Often, studies lack a detailed …

Recently, methods have been developed enabling the characterization of the nociceptive
function at the detection threshold level by measuring nociceptive detection thresholds …