Mouse neural stem cell differentiation and human adipose mesenchymal stem cell transdifferentiation into neuron-and oligodendrocyte-like cells with myelination …

AK Santos, KN Gomes, RC Parreira, S Scalzo… - Stem Cell Reviews and …, 2022 - Springer
Stem cell therapy is an interesting approach for neural repair, once it can improve and
increase processes, like angiogenesis, neurogenesis, and synaptic plasticity. In this regard …

In vitro models for neurogenesis

H Azari, BA Reynolds - Cold Spring Harbor perspectives …, 2016 - cshperspectives.cshlp.org
The process of generating new neurons of different phenotype and function from
undifferentiated stem and progenitor cells starts at very early stages of development and …

Adult hippocampal neural stem and progenitor cells regulate the neurogenic niche by secreting VEGF

ED Kirby, AA Kuwahara, RL Messer… - Proceedings of the …, 2015 - National Acad Sciences
The adult hippocampus hosts a population of neural stem and progenitor cells (NSPCs) that
proliferates throughout the mammalian life span. To date, the new neurons derived from …

High-throughput method for automated colony and cell counting by digital image analysis based on edge detection

P Choudhry - PloS one, 2016 - journals.plos.org
Counting cells and colonies is an integral part of high-throughput screens and quantitative
cellular assays. Due to its subjective and time-intensive nature, manual counting has …

Functional consequences of radiation-induced oxidative stress in cultured neural stem cells and the brain exposed to charged particle irradiation

BP Tseng, E Giedzinski, A Izadi, T Suarez… - Antioxidants & redox …, 2014 - liebertpub.com
Aims: Redox homeostasis is critical in regulating the fate and function of multipotent cells in
the central nervous system (CNS). Here, we investigated whether low dose charged particle …

Conductive collagen-based hydrogel combined with electrical stimulation to promote neural stem cell proliferation and differentiation

X Xu, L Wang, J Jing, J Zhan, C Xu, W Xie… - … in Bioengineering and …, 2022 - frontiersin.org
Injectable biomimetic hydrogels are a promising strategy for enhancing tissue repair after
spinal cord injury (SCI) by restoring electrical signals and increasing stem cell differentiation …

CircRNA EPHB4 modulates stem properties and proliferation of gliomas via sponging miR‐637 and up‐regulating SOX10

C Jin, J Zhao, ZP Zhang, M Wu, J Li, B Liu… - Molecular …, 2021 - Wiley Online Library
Gliomas are the most common type of primary brain tumors. CircRNA ephrin type‐B receptor
4 (circEPHB4) is a circular RNA derived from the receptor tyrosine kinase EPHB4. However …

Deep learning and transfer learning for automatic cell counting in microscope images of human cancer cell lines

F Lavitt, DJ Rijlaarsdam, D van der Linden… - Applied Sciences, 2021 - mdpi.com
In biology and medicine, cell counting is one of the most important elements of cytometry,
with applications to research and clinical practice. For instance, the complete cell count …

Fetal gene therapy using a single injection of recombinant AAV9 rescued SMA phenotype in mice

A Rashnonejad, GA Chermahini, C Gündüz, H Onay… - Molecular Therapy, 2019 - cell.com
Symptoms of spinal muscular atrophy (SMA) disease typically begin in the late prenatal or
the early postnatal period of life. The intrauterine (IU) correction of gene expression, fetal …

Critical points for optimizing long-term culture and neural differentiation capacity of rodent and human neural stem cells to facilitate translation into clinical settings

K Radoszkiewicz, V Hribljan, J Isakovic, D Mitrecic… - Experimental …, 2023 - Elsevier
Despite several decades of research on the nature and functional properties of neural stem
cells, which brought great advances in regenerative medicine, there is still a plethora of …