Rheumatoid arthritis is a chronic autoimmune disease that causes progressive articular
damage, functional loss, and comorbidity. The development of effective biologics and small …

Rheumatoid arthritis is the most common inflammatory arthritis and is a major cause of
disability. It existed in early Native American populations several thousand years ago but …

We define the chromatin accessibility and transcriptional landscapes in 13 human primary
blood cell types that span the hematopoietic hierarchy. Exploiting the finding that the …

Recent years have seen considerable advances in our understanding of both the clinical
and basic-research aspects of rheumatoid arthritis. Clinical progress has come from a better …

Objective To examine the efficacy and safety of different rituximab doses plus methotrexate
(MTX), with or without glucocorticoids, in patients with active rheumatoid arthritis (RA) …

Objective: To quantify the influence of cigarette smoking on the risk of developing
rheumatoid arthritis (RA). Methods: 679 cases and 847 controls included during May 1996 …

Objective To study the quantitative and phenotypic reconstitution of peripheral blood B cells
and its relationship to the dynamics of clinical response in patients with rheumatoid arthritis …

CD20 mAb-mediated B cell depletion is an effective treatment for B cell malignancies and
some autoimmune diseases. However, the full effects of B cell depletion on natural, primary …

B-cell-targeted therapy for autoimmune disease emerged from theoretical proposition to
practical reality between 1997 and 1998, with the availability of the B-cell-depleting …

Objective To assess the 6-month effectiveness of the first rituximab (RTX) course in
rheumatoid arthritis (RA) and to identify possible predictors of response. Method 10 …