Osteoarthritis (OA) is an age-related disease, characterized by cartilage degeneration. The
pathogenesis of OA is complicated and the current therapeutic approaches for OA are …

Osteoarthritis (OA) is one of the most prevalent joint disorders associated with the
degradation of articular cartilage and an abnormal mechanical microenvironment …

Background The role of BMAL1 in various diseases remains unclear, particularly its impact
on sepsis-induced acute kidney injury (AKI). This study aims to investigate the role of BMAL1 …

Purpose: Chondrocytes (CHs) in cartilage undergo several detrimental events during the
development of osteoarthritis (OA). However, the mechanism underlying CHs regeneration …

Background The cartilage stem/progenitor cells (CSPC) play a critical role in maintaining
cartilage homeostasis. However, the effects of phenotypic fluctuations of CSPC on cartilage …

Background: In Graves' orbitopathy (GO), localized orbital inflammation within the fixed orbit
often leads to a fibrotic phenotype resulting in restrictive myopathy or refractory proptosis …

Cartilage defects and osteoarthritis are health problems which are major burdens on health
care systems globally, especially in aging populations. Cartilage is a vulnerable tissue …

Alkaptonuria (AKU) is a genetic disorder that affects connective tissues of several body
compartments causing cartilage degeneration, tendon calcification, heart problems, and an …

Background Cilia loss and impaired motile ciliary functions are among the typical
pathological features of chronic rhinosinusitis with nasal polyps (CRSwNP). IL17A and IL22 …

Recent studies have implicated a crucial role of Hippo signaling in cell fate determination by
biomechanical signals. Here we show that mechanical loading triggers the activation of a …