Macrophages are a major component of the tumor microenvironment and orchestrate
various aspects of immunity. Within tumors, macrophages can reversibly alter their endotype …

Macrophages as innate immune cells and fast responders to antigens play a central role in
protecting the body from the luminal content at a huge interface. Chronic inflammation in …

Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …

Monocytes/macrophages are innate immune cells that play a crucial role in the resolution of
inflammation. In the presence of the Th2 cytokines interleukin-4 (IL-4) and interleukin-13 (IL …

T cell–based immunotherapy holds promise for treating solid tumors, but its therapeutic
efficacy is limited by intratumoral immune suppression. This immune suppressive tumor …

Gastric cancer (GC) represents the fifth cause of cancer-related death worldwide. Molecular
biology has become a central area of research in GC and there are currently at least three …

Tumour microenvironment (TME) is a key determinant of tumour growth and metastasis.
TME could be very different for each type and location of tumour and TME may change …

Leukocytes migrate through most tissues in the body, a process which takes place in 3D
environments. We have previously shown that macrophages use the amoeboid migration …

The Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves
as a cornerstone in cellular signaling, regulating physiological and pathological processes …

Alternative activation of macrophages plays an important role in a range of physiological
and pathological processes. This alternative phenotype, also known as M2 macrophages, is …