I. Executive Summary Background The 5 years since the publication of the first International
Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR‐RS) has witnessed …

Knowledge of chronic rhinosinusitis (CRS) epidemiology may directly impact patient care:
aiding patient identification and establishing accurate diagnosis as well as informing …

Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by IgE
hyperproduction and eosinophilic inflammation. The anti-IgE antibody, omalizumab, has …

Chronic rhinosinusitis (CRS) affects up to 12% of the general population and is traditionally
divided into two main phenotypic subsets, based on the presence of nasal polyps …

Chronic rhinosinusitis (CRS) is an inflammatory disease of the sinonasal mucosa. It is likely
due to a dysregulated immune response directed against, and also modified by, antigens …

Abstract Purpose of Review Chronic rhinosinusitis is a disease with high prevalence,
significant impact on health-related quality of life (HRQoL) and it is associated with …

Background Previous studies have identified subdomains of the 22‐item Sino‐Nasal
Outcome Test (SNOT‐22), reflecting distinct and largely independent categories of chronic …

Nasal obstruction (NO) is defined as the subjective perception of discomfort or difficulty in
the passage of air through the nostrils. It is a common reason for consultation in primary and …

Introduction Control is an important concept and outcome measure for chronic incurable
diseases, defined as the extent to which manifestations of a disease are within acceptable …

Objective To determine the minimal clinically important difference (MCID) of the 22‐item
Sinonasal Outcome Test (SNOT‐22) in individuals undergoing medical management for …