Quinolone antimicrobials are synthetic and widely used in clinical medicine. Resistance
emerged with clinical use and became common in some bacterial pathogens. Mechanisms …

Quinolone antimicrobials are widely used in clinical medicine and are the only current class
of agents that directly inhibit bacterial DNA synthesis. Quinolones dually target DNA gyrase …

Proteus spp. are commensal Enterobacterales of the human digestive tract. At the same
time, P. mirabilis is commonly involved in urinary tract infections (UTI). P. mirabilis is …

The free-floating extracellular DNA (exDNA) fraction of microbial ecosystems harbors
antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs). Natural …

While the description of resistance to quinolones is almost as old as these antimicrobial
agents themselves, transferable mechanisms of quinolone resistance (TMQR) remained …

After two decades of the discovery of plasmid-mediated quinolone resistance (PMQR), three
different mechanisms have been associated to this phenomenon: target protection (Qnr …

Quinolones are a family of synthetic broad-spectrum antimicrobial drugs. These molecules
have been widely prescribed to treat various infectious diseases and have been classified …

Background Quinolones are broad-spectrum antibiotics, which are used for the treatment of
different infectious diseases associated with Enterobacteriaceae. During recent decades …

Objectives Antibiotic-polluted environments may function as reservoirs for novel resistance
plasmids not yet encountered in pathogens. The aims of this study were to assess the …

“Antibiotic resistance is usually associated with a fitness cost” is frequently accepted as
common knowledge in the field of infectious diseases. However, with the advances in high …