Animals transmit not only DNA but also other molecules, such as RNA, proteins and
metabolites, to their progeny via gametes. It is currently unclear to what extent these …

Examples of transgenerational inheritance of environmental responses are rapidly
accumulating. In Caenorhabditis elegans nematodes, such heritable information transmits …

The transparency of Caenorhabditis elegans provides a unique window to observe and
study the function of germ granules. Germ granules are specialized ribonucleoprotein (RNP) …

Abstract dsRNA-mediated gene silencing is heritable in Caenorhabditis elegans, termed
RNAi inheritance. Spracklin et al. describe the results of a forward genetic... Gene silencing …

Over the last 20 years, studies of Caenorhabditis elegans natural diversity have
demonstrated the power of quantitative genetic approaches to reveal the evolutionary …

It is unknown whether transient transgenerational epigenetic responses to environmental
challenges affect the process of evolution, which typically unfolds over many generations …

The animal germline lineage needs to be maintained along generations. However, some
Caenorhabditis elegans wild isolates display a mortal germline phenotype, leading to …

RNAi-elicited gene silencing is heritable and can persist for multiple generations after its
initial induction in C. elegans. However, the mechanism by which parental-acquired trait …

piRNAs play a critical role in the regulation of transposons and other germline genes. In
Caenorhabditis elegans, regulation of piRNA target genes is mediated by the mutator …

The Caenorhabditis elegans genome encodes nineteen functional Argonaute proteins that
use 22G-RNAs, 26G-RNAs, miRNAs or piRNAs to regulate target transcripts. Only one …