Angiogenesis is an important component in the development of thyroid goitre. Vascular
endothelial growth factor (VEGF) represents a family of specific endothelial cell mitogens …

Glucocorticoids (GCs) are steroidal ligands for the GC receptor (GR), which can function as
a ligand-activated transcription factor. These steroidal ligands and derivatives thereof are …

The cyclin-dependent kinase inhibitor p21WAF1/CIP1 (p21) is a cell-cycle checkpoint
effector and inducer of senescence, regulated by p53. Yet, evidence suggests that p21 could …

The identification of key genes in transcriptomic data constitutes a huge challenge. Our
review of microarray reports revealed 88 genes whose transcription is consistently regulated …

The stress-activated protein kinase p38 stabilizes a number of mRNAs encoding
inflammatory mediators, such as cyclooxygenase 2 (Cox-2). In HeLa cells the anti …

The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor present in
most cell types. Upon ligand binding, the GR is activated and translocates into the nucleus …

There is a broad consensus that glucocorticoids (GCs) exert anti-inflammatory effects largely
by inhibiting the function of nuclear factor κB (NFκB) and consequently the transcription of …

Background Increased airway smooth muscle bulk is a pathological feature of asthma.
Asthma is well controlled by the combined inhalation of glucocorticoids and β 2 …

To determine the effect of dexamethasone on the antimyeloma effects of lenalidomide, we
tested in vitro proliferation, tumor suppressor gene expression, caspase activity, cell cycling …

Background Increased proliferation of bronchial smooth-muscle cells may lead to increased
muscle mass in the airways of patients with asthma. The antiproliferative effect of …